General Information

  • ID:  hor003516
  • Uniprot ID:  Q9NL83
  • Protein name:  Orcokinin
  • Gene name:  NA
  • Organism:  Procambarus clarkii (Red swamp crayfish)
  • Family:  Orcokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Procambarus (genus), Cambarinae (subfamily), Cambaridae (family), Astacoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  NFDEIDRSGFGFN
  • Length:  13
  • Propeptide:  MTAQMFTIALLLSLSAIAAAGTIKTAPARTPSTQDDASFPPDGAPVKRFDAFTTGFGHSKRNFDEIDRSGFGFAKKNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFNKRNFDEIDRSGFGFVKRVYVPRYIANLYKRNFDEIDRSGFGFNKRNFDEIDRTGFGFHKRDYDVFPDKRNFDEIDRSGFGFVRRNVE
  • Signal peptide:  MTAQMFTIALLLSLSAIAAA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic peptides that enhance both the frequency and amplitude of spontaneous hindgut contractions
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9NL83-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003516_AF2.pdbhor003516_ESM.pdb

Physical Information

Mass: 173179 Formula: C67H92N18O23
Absent amino acids: ACHKLMPQTVWY Common amino acids: F
pI: 3.88 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 4
Hydrophobicity: -82.31 Boman Index: -4011
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 30
Instability Index: 4997.69 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  10753578
  • Title:  Identification of Orcokinin Gene-Related Peptides in the Brain of the Crayfish Procambarus Clarkii by the Combination of MALDI-TOF and On-Line Capillary HPLC/Q-Tof Mass Spectrometries and Molecular Cloning